References

Miriam Rothdiener et al. (2018) Human osteoarthritic chondrons outnumber patient‐ and joint‐matched chondrocytes in hydrogel culture—Future application in autologous cell‐based OA cartilage repair? Journal of Tissue Engineering and Regenerative Medicine 12:e1206-e1220 (Link)

Hellwig, C. et al. (2018) Culture of human neurospheres in 3D scaffolds for developmental neurotoxicity testing. Toxicology in vitro 52:106-115 (Link)

Grobe, H. et al. (2018) A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions. PLoS One 13:e0194716 (Link)

Friedrich, O. et al. (2017) Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling. Progress in Biophysics and Molecular Biology 130:170-191 (Link)

Sardi, M. et al. (2016) Modeling Human Immunity In Vitro: Improving artificial lymph node physiology by stromal cells. Applied In Vitro Toxicology. July 2016, ahead of print. doi:10.1089/aivt.2016.0004. (link)

3-D Life Hydrogel is used to develop an artificial lymph node model using a perfused bioreactor system.

Koenig, G., et al. (2016) Cell-laden hydrogel/titanium microhybrids: Site-specific cell delivery to metallic implants for improved integration. Acta Biomater. 2016 Mar;33:301-10. doi: 10.1016/j.actbio.2016.01.023. Epub 2016 Jan 21. (link)

Co-culture of HUVECs and fibroblasts in 3-D Life Hydrogels to assess titanium-hydrogel-cell compatibility for future implantation strategies.

Grikscheit, K. et al. (2015) Junctional actin assembly is mediated by Formin-like 2 downstream of Rac 1. J. Cell Biol. 209:367-76. (PubMed)

Molecular mechanisms of de novo epithelial lumen formation is studied in long term cultures of MCF10A mammary epithelial cells in 3-D Life Hydrogels.

Charwat, V. et al. (2015) Potential and limitations of microscopy and Raman spectroscopy for live-cell analysis of 3D cell cultures. J. Biotechnol. 2015 Feb 14. [Epub ahead of print] (link)

Cancer cells and fibroblasts are analyzed alone and in co-culture in 3-D Life Hydrogels using Raman spectroscopy.

Sun, J. et al. (2014) Geometric control of capillary architecture via cell-matrix mechanical interactions. Biomaterials. 35:3273-80. ()

3-D Life Dextran-PEG Hydrogel was mixed with Matrigel to adjust the stiffness of Matrigel while maintaining the ligand density for cell adhesion.

Rimann, M. et al. (2014) Automation of 3D Cell Culture Using Chemically Defined Hydrogels. J. Lab. Autom. 19:191-197 (link)

Automated drug screening of tumor spheroids in 3-D Life Hydrogels. Demonstrates the different drug sensitvities of tumor cells in 2-D versus 3-D cell culture.

Ueda, E., et al. (2012) DropletMicroArray:Facile Formation of Arrays of Microdroplets and Hydrogels Micropads for Cell Screening Applications. Lab Chip 12:5218-5224 (PubMed)

Preparation of hydrogel microarrays with 3-D Life Hydrogel for research and high-throughput screening.

Rimann, M., Graf-Hausner, U. (2012) Synthetic 3D Multicellular Systems for Drug Development. Curr. Opin. Biotechnol. 23:803-809 (PubMed)

Review on synthetic 3D culture systems, including 3-D Life Hydrogel.

Neugebauer, U., et al. (2012) From Infection to Detection: Imaging S aureus-host Interactions. Biomed. Tech. (Berl) (link)

3-D Life Hydrogel is used to immobilize bacteria for Raman spectroscopy.

Benz, K., et al. (2010) Polyethylene Glycol-Crosslinked Serum Albumin/Hyaluronan Hydrogel for the Cultivation of Chondrogenic Cell Types. A Adv. Eng. Mater. 12:B539-B551 (link)

3-D Life Hydrogel technology is used with maleimide-modified serum albumin for the cultivation of chondrogenic cells.

Scholz, B., et al. (2010) Suppression of Adverse Angiogenesis in an Albumin-based Hydrogel for Articular Cartilage and Intervertebral Disc Regeneration. Eur. Cell. Mater. 20:24-37 (download)

3-D Life Hydrogel technology used with maleimide-modified serum albumin.