|Wang et al. (2019) Characterization and Analysis of Collective Cellular Behaviors in 3D Dextran Hydrogels with Homogenous and Clustered RGD Compositions. Biomaterials 35(10): 3273–3280. (Article)|
The authors took an innovative approach and used the flexibility of the 3-D Life Hydrogel system to design a clustered RGD Peptide microenvironment to study patterns of cell adhesion ligands on cell behavior. Cells Used: NIH–3T3 fibroblasts, C2C12 cells (myoblasts, murine). Methods used: Live/Dead viability assay, bright-field and confocal microscopy, phalloidin staining, DAPI staining.