Huang et al. (2018) Three-dimensional hydrogel is suitable for targeted investigation of amoeboid migration of glioma cells. Mol Med Rep.17:250-256 (Article)

3-D Life Dextran-CD hydrogel modified with RGD Peptide was used to quantitatively evaluate amoeboid versus mesenchymal cell migration of glioma cells. The work shows how 3-D Life Hydrogel, in contrast to 2D culture, supports drug evaluation aiming at the efficient inhibition of both, amoeboid and mesenchymal cell migration in 3D culture. Applications: drug evaluation, cell migration analysis. Methods used: immunofluorescent staining, fluorescence microscopy, chemotaxis in ibidi µ-slides (